I-RS-422 (TIA/EIA-422) inesivinini esiphezulu, ukumelana nomsindo okungcono nobude bekhebula ende kunezinga elidala le-RS-232C.
Uhlelo lwe-RS-422 lungadlulisela idatha ngamanani afika ku-10 Mbit/s futhi lungadlulisela idatha kufika kumamitha angu-1,200 (3,900 amafidi). I-RS-422 yayisetshenziswa kabanzi kumakhompyutha okuqala e-Macintosh. Isetshenziswa ngesixhumi esinamaphini amaningi kumadivayisi e-RS-232 njengamamodemu, amanethiwekhi e-AppleTalk, amaphrinta we-RS-422, namanye ama-peripheral.